Influenza is generally a self-limited illness, but complications including pneumonia, respiratory failure, and death can occur, especially in persons at increased risk (see Table 1).
TREATMENT OF INFLUENZA — Three neuraminidase inhibitors (oral oseltamivir, IV peramivir, and inhaled zanamivir) and the oral cap-dependent endonuclease inhibitor baloxavir marboxil are available in the US and are recommended for treatment of influenza this season (see Table 2).1
Antiviral...
ISSUE
The FDA has approved the oral Janus kinase (JAK) inhibitor deuruxolitinib (Leqselvi – Sun) for treatment of severe alopecia areata in adults. Two other oral JAK inhibitors are approved for treatment of severe alopecia areata: baricitinib (Olumiant) is approved for use in adults,1 and ritlecitinib (Litfulo) is approved for use in patients ≥12 years old.2
THE DISORDER — Alopecia areata is an autoimmune disorder characterized by rapid hair loss that results in patches of baldness on the scalp, eyebrows, and eyelashes and sometimes in total hair loss.
STANDARD TREATMENT — Topical immunotherapy with diphenylcyclopropenone or squaric acid dibutyl ester is generally the first-line treatment for severe alopecia areata.3 Intralesional or topical corticosteroids can be added for spot treatment, but data supporting their efficacy are …